Precision medicine in severe pediatric asthma

Precision medicine in pediatric oncology

PURPOSE OF REVIEW The current review describes recent advances and unique challenges in precision medicine for pediatric cancers and highlights clinical trials assessing the clinical impact of targeted therapy matched to molecular alterations identified by tumor profiling. RECENT FINDINGS Multiple prospective clinical sequencing studies in pediatric oncology have been reported in the last 2 y...

Asthma-COPD overlap syndrome and precision medicine.

Differentiation of asthma and chronic obstructive pulmonary disease (COPD) in symptomatic patients has been extremely difficult clinically in many instances. This situation led to the formulation of the so-called “Dutch hypothesis” in 1961,1 cited by Christenson.2 The theory postulates that obstructive lung disease occur in a continuum, with asthma and COPD being expressions of the same disease...

Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine

Pediatric cancers differ from adult tumors, especially by their very low mutational rate. Therefore, their etiology could be explained in part by other oncogenic mechanisms such as chromosomal rearrangements, supporting the possible implication of fusion genes in the development of pediatric cancers. Fusion genes result from chromosomal rearrangements leading to the juxtaposition of two genes. ...

Precision medicine, technologies, and molecular diagnostics

Introduction: Genetics, cellular and molecular medicines are cutting-edge sciences and technologies that play an important role in improving human health and quality of life. In addition, medical and biological sciences have clearly shown that the onset of diseases differs from person to person due to their different genetic profiles and variations in molecular basis. Therefore, it is feasible ...

Severe Chronic Asthma: Chiropractic Care in a Pediatric Case